Rune comes in three types:

1) 2) 3)

They can be added to items that have the corresponding slots.

Items that can have slots: Dragon set (Max 2 slots), Legendary set (Max 2 slots), Guardian set (Max 2 slots), Storm Crow set (Max 2 slots), Adamantine set (Max 2 slots), Red Wing set (Max 2 slots), Black Dragon set (Max 1 slot), Dark Phoenix set (Max 1 slot), Grand Soul set (Max 1 slot), Divene set (Max 1 slot), Thunder Hawk set (Max 1 slot), Dark Steel set (Max 1 slot), Ancient set (Max 1 slot).

To add or remove a Rune from an item, you will need to contact a Rune Researcher, who can be found in Noria 178 127